Genetic analysis of human parainfluenza virus type 4 associated with severe acute respiratory infection in children in Luohe City, Henan Province, China, during 2017–2018

Abstract During 2017–2018, nasopharyngeal aspirates (NPAs) from 627 hospitalized patients with severe acute respiratory infection at Luohe Center Hospital were tested by RT-PCR for human parainfluenza virus 4 (HPIV-4). Fourteen (2.2%) of the samples positive HPIV-4. The complete HN gene was amplified nine and sequenced. Sequence comparisons showed that HPIV-4 strains circulating in city are closely related to HPIV-4A strains. Our study indicated there multiple lineages Henan Province China during period. This will improve our understanding epidemiological clinical characteristics